Overview

Jan Marini Skin Research is a privately held personal care products manufacturer that specializes in skin care items, such as C-ESTA, Age Intervention, and Bioglycolic. The firm also markets a line of professional and clinical products that are available only by prescription. The company was founded by Jan Marini in the year 1994. Located in San Jose, CA, Jan Marini Skin Research has quickly grown in size from a small office in California to a "world-renowned power in the market with employees across the county and distributors around the world" with estimated sale of $7.6 million (est.). It products are sold through distributors in more than 80 countries around the world and directly to physicians and licensed skin care professionals.

Product Lines

Bioglycolic Line includes products based on a glycolic acid also known as an "alpha hydroxy acid" or "AHAs" that occur naturally in various fruits and foods. Glycolic acid that was found in sugar cane has received the most medical attention because of its small molecule size which allows glycolic acid to penetrate more effectively and to bring about the most dramatic and beneficial change. Compared to other AHAs (glycolic acid) it has the greatest effect compared to any other source. One other property of the glycolic acid is its loosening property on the glue-like attachments that is characteristic of many skin conditions including acne, environmental aging (photodamage), and hyper- pigmentation. This allows glycolic acid to act as a phenomenal resurfacing agent that can improve appearance of the skin and potentially reduce the depth of acne scarring among its many other positive effects. Jan Marini has created Bioglycolic products to deliver the above benefits to its customers.

C-Esta Line is based on a long established medical fact about the role Vitamin C plays in skin's functioning. Vitamin C is essential for skin's protection from UV damage and rejuvination from sun-induced aging factors. Furthermore, Vitamin C has been proven to be transfered into the skin cells through topical application. Topical application is a complex process involving stabilization, optimum skin absorption and adequate levels of activity. C-ESTA containing DAE Complex is the result of 12 years of medical research resulting in the first stabilized form of lipid soluble topically applied Vitamin C in a patented delivery vehicle, combined with other essential factors.

The Age Intervention Line is an anti-aging technology designed for adult women. It addresses the appearance of aging skin changes by targeting hormonal levels and changes associate with sun exposure. As females age and hormonal levels drop, the atrophy of sebaceuous glands contribute to drier skin. Furthermore, the declining levels of estrogen results in lower moisture content thus contributing to the formation of fine lines and wrinkles. Thinning of dermis, sparser elastin fibers, variations in collagen production are among other hormonally related changes that occur in adult women. The second aspect of the aging skin process is the sun exposure. Two major factors are involved in photo damaged skin are impaired immune function and inflammatory actions. The Age Intervention Line addresses the above factors by recapturing the skin's normal hormonal balance and boosting the skin's ability to repair damage and preventing certain inflammatory actions by using a combination of topical agents.

Transformation Line focuses on Transformation Growth Factor (TGF Beta-1), Thymosin Beta-4, Pentapeptides, and Vascular Epithelial Growth Factor (VGF) to deliver a breakthrough in anti-aging technology. TGF Beta-1 is a form of cytokine technology that is believed to have properties of a cellular mediator by signaling certain cellular activities like those necessary to retain the appearance of young, healthy skin. One medical researcher believes that TGF Beta-1 may be the answer to keeping skin young indefinitely. Thymousin Beta-4 is a string of 43 amino acid peptides that assist in regulating immune cells and is also a powerful anti-inflammatory and wound healing agent. On-going research has demonstrated its effect on aging skin, because of its ability to communicate cells and direct important aspects of critical functions, reducing free radical activity and by stimulating the production of collagen and elastin. Pentapeptides are tiny strings of amino acids that can communicate with cells by directly improving or correcting instructions that the cell needs in order to function properly. Unlike other peptides, we can now selectively define the scope of each individual peptide thus virtually programming the desired type of repair or assistance. Vascular Growth Factor is a polypeptide that assists in stimulating new blood vessel formation by helping to regulate angiogenesis which is critical for repairing wounds or damaged skin. The Transformation Line utilizes the breakthroughs in skin care research in the area of instructions that are transmitted to cells and the cell's ability to interpret and carry out the instructions, hopefully resulting in more normal, healthy and young looking skin.

Antioxidant Group is the result of medical research in the area of antioxidants and their value in helping to reverse and prevent free radical damage. Free radicals are highly unstable oxygen molecules with unpaired electrons that seek other molecules with stable electrons to achieve their own stabilization. As a result of free radicals attaching to a normal molecule, this molecule is transformed into another free radical whose function and shape is now altered. The damage caused by the free radicals can range from cell damage to ultimately cellular death. The effects of free radical activity are manifested by lines, wrinkles, dry skin, loss of elasticity, and skin discoloration. Antioxidants have the capability of interrupting or preventing the effects of free radicals. They provide electrons to the free radicals so that they could be neutralized before they destroy other molecules. Jan Marini Skin Research has developed the antioxidant product group by using substances that have benefits to aid in preventing one of the primarily sources of cellular damage and aging.

Factor-A and Factor-A Plus fall into the category of Retinoids. Retinoids are a group of naturally occurring and synthetic compounds that have Vitamin A like biological activity. They play a critical role in skin growth, repai and epithelial cell differentiation. The most well know Retinoic acid compound is Retin-A. Retinoic acid has proven to be effective prescription medication. Unfortunately this compound has effects of mild to extreme redness and irritation. Recently numerous university medical and research facilities have reported that Retinol has the activity and efficacy of retinoic acid without the majority of the side effects associated with Retin-A. Jan Marini Skin Research has identified new stabilization and delivery components that enable Retinol to be delivered in a stable fashion where it is converted into retinoic acid while avoiding redness, peeling and irritation. Retinol has proven to be a potent tool in treating acne by preventing the cells that line the follicular canal from sticking together and creating the solid impactions that block the follicle. Factor-A and Factor-A Plus contain the highest percentages of Retinol legally available.

The Benzoyl Peroxide Group is a potent and effective therapy for treating acne. Benzoyl Peroxide is recognized by the American Academy of Dermatology as being one of the most effective antibacterial agents to significantly reduce the presence of P acne bacteria. P acne Bacteria is believe to play a primary role in the inflammatory aspect of the acne process. P acne bacteria thrives in an oxygen free environment and feeds on trapped oil in the sebaceous follicle. It releases a toxic and corrosive by-product that works to break down the follicle walls and encourage the leaks and ruptures that produce acne lesions. The Benzoyls Peroxide Group works by reducing the P acne bacteria colonies, thus reducing the inflammatory process and clearing acne lesions.

EnzymeLine utilizes Proteolytic enzymes proven to be the most effective method of supplemental exfoliation at home. Proteolytic refers to an enzymatic reaction that can digest dead protein material without harming healthy cells. A common source of proteolytic enzyme is papain. Until now, green papaya could never be harvested and formulated in a manner that would maintain the essential activity. Jan Marini Skin Research has located and utilized the only available source for this sensitive technology.

Awards

• The Technical Exhibit Award from the American Society of Plastic recognizing "exceptional merit in company identity, product and aesthetic presentation, and personnel professionalism."
• The Hank Tadesco Small Business Excellence Award from the Silicon Valley Chamber of Commerce.
• Name the Number 6 Woman-Owned Business in the Silicon Valley in 2005.
• The San Jose Business Journal honored Jan Marini with the Woman of Distinction award for Small Business in 2005
• Honored by the American Business Association's Stevie Award recognizing one of the Support Staffer of the Year for 2003.

Contact Information

Jan Marini Skin Research
6951 Via Del Oro
San Jose, CA 95119

Phone: 408-362-0130
Fax: 408-362-0140
Toll Free: 800-347-2223